3/23/2023 0 Comments Quickscale columns![]() These empty chromatography columns are also compatible with other high performance liquid chromatography systems that have the appropriate pressure capacity. The user-friendly design of the HiScale™ column facilitates trouble-free operation, with fittings for direct connection to ÄKTA systems. ÄKTA system and other chromatography system compatibility For columns packed with SOURCE 15 and SOURCE 30, a 10 µm net ring should be used. HiScale™ chromatography columns are compatible with all Cytiva resins. Resin compatibility for medium to high pressure liquid chromatography The robust design of HiScale™ 10/40 allows for controlled bed heights and gives reproducible results offering an effective scaled down model of the large-scale downstream process. The small inner diameter and flexible adapters minimize costly sample and viral spike volumes. HiScale™ 10/40 columns are especially suitable for scaledown studies used in, for example, viral clearance evaluation in downstream processing. Viral clearance and other scaledown studies with HiScale™ 10/40 They are compatible with all methods currently applicable to XK columns. HiScale™ columns are based on the well‐established line of XK columns. The column’s measurement scale helps users to predict and reach a predefined bed height. The entire shaft may be rinsed after column packing, minimizing the risk of bacterial growth. The QuickLock mechanism of the adapter shaft facilitates rapid and easy movement of the adapter, simplifying adjustments as well as disassembly and cleaning. These chromatography columns withstand pressures up to 20 bar, with a user‐friendly design that supports process optimization through simplified and reproducible operations. HiScale™ pressure‐stable, empty columns are designed for process development and preparative chromatography using ÄKTA protein purification systems. HiScale™ column design for medium to high pressure liquid chromatography ![]() High flexibility: equipped with two adapters allowing for a large range of bed heights. Scalable: the HiScale™ column range is designed to facilitate robust process scaleup, as well as cost-efficient and accurate scaledown for applications such as viral clearance studies Variety of column dimensions: choose from 10, 16, 26, or 50 mm inner diameter, and 200 mm or 400 mm length to accommodate bed volumes up to 785 mL Versatile: dual adapters and axial compression capability allow for a large range of bed heights and column packing protocols ![]() Pressure-stable: built to withstand pressures up to 20 bar (2 MPa, 290 psi) for compatibility with modern BioProcess™ resins HiScale™ empty chromatography columns are a family of pressure-stable, easy to pack, columns for medium to high pressure liquid chromatography using a chromatography system.Įasy to pack: convenient column measurement scale, nonrotating plunger mechanism, and ergonomically designed components for easier adjustment during column packing ![]()
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